I have a 2006, 2500 diesel, 155K I have popped the P0201 and P2146 codes twice now. About 6 months ago, it was 0 degrees out and I did not let my truck warm up and hit the freeway and it started running rough. Next day ran OK and shop checked it out and could not find any issues. About 1 week ago, I filled up with fuel, (not usual station, rain the night before) and popped the codes again after about 3 blocks. I opened the valve below fuel filter, could not tell if there was water. I limped into town looking for a shop and it started running better. Got to autoparts store and got new fuel filter and some fuel additive. Runs just fine now.

Could these issue just have been jelled fuel and water in the fuel?
If is not, how do I know if it is the injectors or the wiring in valve cover? These are all big bucks and do not want to throw money around.

Thanks!!

 

could be your valve cover gasket, I think dodge made a improved one.
Genos garage has one for about 100 bucks

 

its injectors. Go buy a laser thermometer. there cheap like 30-40. with truck running point it at manifold just outside block. if you see temps all over the place its injectors. Do all 6. I got mine off a company in FL off ebay. trucks runs awesome. I have read injectors on these trucks can go as early as 50k. So 160k do all 6. I paid 1100 for 6. that's oem stock spec